Purity ~98% (SDS-PAGE, HPLC). MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Source: Recombinant protein corresponding to human MIA, a globular protein containing 108aa residues including two intramolecular disulfide bonds, expressed in E. coli. Molecular Weight: ~12.2kD Biological Activity: Determined by the inhibitory effect on the invasion of Mel in tumor cells and found active in Mel in assay