Purity ~95% (SDS-PAGE). MIA is a secreted, regulatory protein produced mainly by chondrocytes and malignant melanoma cells. This protein induces the metastasis of cancer cells by indirectly causing the detachment of melanoma cells from the surrounding extracellular matrix. MIA levels are now measured and used as a diagnostic tool for melanoma metastasis and rheumatoid arthritis. Source: Recombinant protein corresponding to human MIA expressed in E. coli. Molecular Weight: ~12.4kD Endotoxin: <1EU/ug (LAL)