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Description
Mouse Anti-DCC Recombinant Antibody (AXEL1). Provided herein is a Mouse monoclonal antibody, which binds to DCC Netrin 1 Receptor (DCC). The antibody can be used for immunoassay techniques, such as FC, FuncS. DCC is a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated
Immunogen
Recombinant human DCC fibronectin domain 5
Other Names
DCC Netrin 1 Receptor; Immunoglobulin Superfamily DCC Subclass Member 1; Deleted In Colorectal Carcinoma; Colorectal Cancer Suppressor; Tumor Suppressor Protein DCC; IGDCC1; Immunoglobulin Superfamily, DCC Subclass, Member 1; Putative Colorectal Tumor Suppressor;