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Description
Can be used to specifically detect both the unmodified (~ 70kD) form and the GMP1 (SUMO-1) conjugated (~90kD) form of the RanGAP-1 protein. The ~70kD form of RanGAP-1 is cytoplasmic, whereas the ~90kD form is associated predominately with the nuclear envelope where it is localized to the nuclear pore complexes (NPCs). Species crossreactivity: human and rat. Lysates Tested: Rat liver nuclear envelopes, total lysates derived from NIH 3T3 and HeLa cells.
Immunogen
A fusion protein consisting of the first 203 amino-terminal residues of the mouse RanGAP-1 protein.