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Description
Mouse Anti-KPNA4 Recombinant Antibody (CBYC3-112). Provided herein is a Mouse monoclonal antibody against Human KPNA4. The antibody, clone CBYC3-112, can be used for immunoassay techniques, such as WB. KPNA4 is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. KPNA4 binds specifically and directly to substrates containing either a simple or bipartite NLS motif and functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.