Psenen is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Size
100 μg
Concentration
n/a
Applications
Western Blotting (WB),Immunohistochemistry (IHC),Blocking Peptide (BP)