Chromatographically purified. A 20-aa peptide sequence within the extracellular, N-terminus of human PS1/S182. The immunogenic peptide sequences from Presenilin-1, shows 100% homology to lemur, 70% (14/20 aa) with mouse and 75% with rat and mouse PS1. Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. A number of genes have been linked in the initiation and development of AD. An early onset of familial AD has been linked to some 30 mutations in two related genes, Presenilins-1 (PS-1 on chromosome 14; 467 aa) and Presenilins-2 (PS-2 on chromosome 1; 448 aa). PS-1/2 have been colocalized in subcellular sites involved in cell cycle regulation and mitosis (the nuclear membrane, interphase kinetochore, and centrosome). Applications: ELISA: 1:10K-1:100K using 50-100ng of control peptide/well.