Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. A number of genes have been linked in the initiation and development of AD. An early onset of familial AD has been linked to some 30 mutations in two related genes, Presenilins-1 (PS-1 on chromosome 14; 467 aa) and Presenilins-2 (PS-2 on chromosome 1; 448 aa). PS-1/2 have been colocalized in subcellular sites involved in cell cycle regulation and mitosis (the nuclear membrane, interphase kinetochore, and centrosome). Source: Synthetic peptide corresponding to 15aa sequence near the C-terminus of human Presenilin 1. Specificity: Sequence is specific for human Presenilin. No significant homology exists with other known proteins. Species Crossreactivity: Xenopus, mouse and rat Presenilin-1 Applications: Suitable for use in ELISA and Antibody Blocking. Not suitable for use in Western Blot due to low molecular weight.