Neuron-specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene. Gamma-enolase is a phosphopyruvate hydratase. Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. . Description: Human brain. Alternative Names: Neural enolase protein, Enolase 2 gamma neuronal protein, Neuron Specific Enolase protein, Neuron specific enolase protein, Enolase 2 protein, gamma-enolase protein, Enolase2 protein, Neuron specific gamma enolase protein , gamma enolase protein