PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist (EC50 values are 3.4 and 2.2 μM, respectively). Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant. Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene. . Purity 98%. MW (observed): 404.38