Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3) (Extracellular Domain)
Clone
polyclonal
Host Species
Sheep
Reactive Species
rat, mouse, human
Isotype
n/a
Format
unconjugated
Size
500 μg
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
Reviews / Ratings
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Description
Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.Subcellular location: Membrane, Single-pass type I membrane protein.Tissue specificity: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. Also known as: Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3.
Immunogen
A synthetic peptide from the extracellular domain of rat TrkC (Trk-C, NTRK3, NT-3 growth factor receptor, GP145-TrkC) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in mouse, human and monkey.