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| Antigenic Specificity | Bestrophin 1 (BEST1) (C-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | FUNCTION: Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. Subcellular location: Cell membrane, Multi-pass membrane protein. Basolateral cell membrane Tissue specificity: Predominantly expressed in the basolateral membrane of the retinal pigment epithelium. Defects in BEST1 are the cause of vitelliform macular dystrophy type 2 (VMD2) also known as Best macular dystrophy (BMD). VMD2 is an autosomal dominant form of macular degeneration that usually begins in childhood or adolescence. VMD2 is characterized by typical 'egg-yolk' macular lesions due to abnormal accumulation of lipofuscin within and beneath the retinal pigment epithelium cells. Progression of the disease leads to destruction of the retinal pigment epithelium and vision loss. Defects in BEST1 are the cause of retinitis pigmentosa type 50 (RP50). Defects in BEST1 are a cause of adult-onset vitelliform macular dystrophy (AVMD). Defects in BEST1 are the cause of bestrophinopathy autosomal recessive (ARB). Defects in BEST1 are the cause of vitreoretinochoroidopathy autosomal dominant (ADVIRC).Synonyms: TU15B, Vitelliform macular dystrophy protein 2, BEST1, VMD2 |
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| Immunogen | A synthetic peptide from c-terminal region of human Bestrophin 1 conjugated to an immunogenic carrier protein was used as the antigen. |
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| Other Names | CG6264|Dbest|Dmel\\CG6264|anon-WO0118547.380|best|dBest1|dbest1|dmBest1|BEST1|VMD2|best-1|ARB|BEST|BMD|RP50|TU15B|Bmd|Vmd2|mBest1 |
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| Gene, Accession # | Gene ID: 7439 |
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| Catalog # | ABIN1841874 |
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| Price | |
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| Order / More Info | Bestrophin 1 (BEST1) (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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