If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
EGFRv3 Polyclonal Antibody. ? Target Background: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn a
Immunogen
KLH conjugated synthetic peptide derived from human EGFRvIII. Immunogen Range: 1-50/1081
Wang, J. et al. (2011) PJMS 27.3, 1576-1587. PubMed: N/A // Wehrenberg-Klee, Eric, et al. Am J Nucl Med Mol Imaging 2015;5(4):379-389. PubMed: 26269775 // Wei, Jian-wei, et al. (2016) Cancer Lett. PubMed: 27317648 // Agnes, Richard S., et al. (2012)Mol Cancer Ther. 11.10:2202-2211. PubMed: 22807580 // Kang, Chun-Sheng, et al.(2016) Cancer Lett. PubMed: 27725228 // Liu et al. (2016) Oncotarge. 7:4680-94. PubMed: 26717039 // Khelwatty et al. (2017) Oncotarget. 8:7666-7677. PubMed: 28032593