DNA was prepared from cell line WM3406. WM3406 is a human metastatic melanoma cell line that displays a mesenchymal morphology. This cell line contains a Q61K mutation at position 61 in the N-RAS gene which causes increased signaling via the extracellular signal-regulated MAPK/ERK kinase pathways to enhance proliferation. This cell line also expresses mutated PTEN gene and is wild type for BRAF, c-KIT and CDK4. WM3406 cells produce xenograft tumors when injected into immunocompromised mice.
Size
10 μg
Concentration
200 ng / μl
Applications
Purified Genomic DNA is suitable for a number of molecular biology applications including but not limited to preparation of genomic libraries, PCR templates, DNA sequencing, DNA fingerprinting, and mutation analysis.
Other Names
Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft