A dual inhibitor of PI3K and mTOR (Kiapps = 2, 46, 3, 10, and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, and mTOR, respectively); inhibits the proliferation of PC3 cells in vitro (EC50 = 0.4 μM); reduces phosphorylation of Akt in mouse brain at 25 mg/kg; reduces tumor growth in a U87 MG/M human glioblastoma mouse xenograft model at >2.2 mg/kg and induces tumor regression at 17.9 mg/kg; reduces tumor growth in an A431 cSCC mouse xenograft model at 25 and 50 mg/kg