Recombinant Human Estrogen receptor beta (ESR2), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 39.8kDa. Partial of Isoform 3: 2-323aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elents (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated tperature is more gradual.