Recombinant Human Estrogen receptor beta (ESR2), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 51.9kDa. Partial of Isoform 3: 2-323aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
ER-beta; Alternative name (s); Nuclear receptor subfamily 3 group A member 2