Recombinant Human E3 SUMO-protein ligase RanBP2 (RANBP2), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 36.8kDa. Partial: 2601-2802aa. N-terminal 6xHis-B2M-tagged. Homo sapiens (Human). E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
358KDA nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2