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Description
Caspase 1 Polyclonal Antibody. Caspase-1/ICE (Interleukin-1Beta Converting Enzyme) is expressed as a proenzyme of 45kDa in many tissues. Upon stimulus, it gets activated by proteolytic cleavage. Active caspase-1 is a tetramer of two subunits p10 and p20 in 2; 2 proportion. Caspase-1 (cystein aspartic-specific protease 1) cleaves its substrates after an aspartate residue. It cleaves Interleukin Beta into its active form which further exerts its proinflammatory effects. Overexpression of caspase-1 can induce apoptosis in fibroblast, which can be inhibited by overexpression of Crm A, a protein from pox virus.