Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal-derived components or impurities. Animal Free product. Recombinant human TGF-beta2 is a 27.08 kDa protein composed of two identical 112 amino acid peptide chains linked by a single disulphide bond. Transforming growth factor-beta is a family of five related cytokines that have been shown on a wide variety of normal and neoplastic cells, indicating the importance of these homo-dimmer proteins as multi-functional regulators of cellular activity. The three mammalian isoforms of TGF-beta (TGF-beta1, TGF-beta2 and TGF-beta3) signal through the same receptor and elicit similar biological responses. They are involved in physiological processes as embryogenesis, tissue remodelling and wound healing. Recombinant human TGF-beta2 is a 27.08 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulphide bond. Purity >97% by SDS-PAGE gel
Size
1ug, 10ug, 100ug
Concentration
n/a
Applications
Functional studies, Cell Culture. Western Blot. Immunogen. Dermocosmetics (Recombinant human TGF beta-2 stimulates the proliferation of fibroblasts, the synthesis of collagen in fibroblasts and induces the synthesis and organization of fibronectin in the extracellular matrix (ECM).
- Ten Dijke, P., et al. (1988). Identification of a new member of the transforming growth factor type beta gene family. Proc. Natl. Acad. Sci. USA, 85: 4715-4719. - Massage, J. (1990). The transforming growth factor-beta family. Ann. Rev. Cell Biol., 6: 597-641. - Miller, D.A., et al. (1990). Transforming growth factor beta: a family of growth regulatory peptides. Ann. N.Y. Acad. Sci., 593: 208-217. - Zhongcheng, Z., Sun, P.D., (2006). An improved recombinant mammalian cell expression system for human transforming growth factor-beta2 and factor-beta3 preparations. Protein Expr. Purif., 50: 9-17