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Description
CCR4 (CC chemokine receptor 4) molecule belongs to the rhodopsin family of G-protein-coupled receptors. Chemokine receptors are membrane bound molecules composed of 7-transmembrane domains and coupled to G-proteins. CCR4 binds the chemokines CCL17 (TARC) and CCL22 (MDC) and is highly expressed in most single-positive CD4(+) thymocytes especially in TH2- and regulatory T-cells. It plays a central role in T cell migration to the thymus, T cell maturation and education. CCR4 is often up-regulated in inflammation and cause conformational changes that trigger intracellular signaling pathways.