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Description
Prostate specific antigen (PSA) belongs to the kallikrein gene family. It is a single-chain glycoprotein with a molecular mass of about 33 kD which is produced by prostate epithelial cells. It is secreted in the seminal plasma and is responsible for liquefaction of the seminal coagulum. PSA is present in small quantities in the serum of healthy males, and is often elevated in the presence of prostate cancer and in other prostate disorders. It is one of the most useful tumour markers because of its tissue specificity. It is thus widely used for screening, diagnosis, and monitoring patients with prostate cancer.