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Description
CBX2 Polyclonal Antibody. ? Target Background: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.
Immunogen
Polyclonal antibody raised in rabbit against mouse CBX2 (chromobox homolog 2) using two KLH-conjugated synthetic peptides containing a sequence from the central region of the protein