Major Intrinsic Protein of Lens Fiber (MIP) (aa 240-280)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
mouse, rat, guinea pig
Isotype
n/a
Format
serum
Size
100 μL
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
Reviews / Ratings
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Description
FUNCTION: Water channel. May be responsible for regulating the osmolarity of the lens. Tissue specificity: Expressed exclusively in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum. Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). SUBCELLULAR LOCATION: Cell membrane, Multi-pass membrane protein. Cell junction > gap junction Tissue specificity: Major component of lens fiber gap junctions.Synonyms: MIP, Lens fiber major intrinsic protein, Aquaporin-0, MIP26, MP26, MIP, AQP0
Immunogen
A synthetic peptide from aa region 240-280 of mouse AQP0 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and guinea pig.