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Description
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. This MED14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-615 amino acids from the Central region of human MED14.
Immunogen
Human MED14.
Other Names
ARC150; Activator-recruited cofactor 150 kDa component; CRSP2; CSP2; Cofactor required for Sp1 transcriptional activation subunit 2; DRIP150; EXLM1; Thyroid hormone receptor-associated protein complex 170 kDa component; Transcriptional coactivator CRSP150; Vitamin D3 receptor-interacting protein complex 150 kDa component; CXorf4; RGR1; TRAP170; Mediator of RNA polymerase II transcription subunit 14; Mediator complex subunit 14; RGR1 homolog; MED14; mediator complex subunit 14; CRSP complex subunit 2; RGR1 homolog; cofactor required for Sp1 transcriptional activation, subunit 2 (150kD); hRGR1; human homolog of yeast RGR1; thyroid hormone receptor-associated protein complex component TRAP170; vitamin D receptor-interacting protein complex component DRIP150; vitamin D3 receptor-interacting protein complex 150 kDa component