CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) (full length) (Active) protein
Description
CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to immunodeficiency with hyper-IgM, a disease characterized by failure to produce IgG, IgA and IgE. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Alternative Names: CD-40, gp39 protein, soluble CD40 Ligand protein, CD 40, CD40, CD 40 protein, TNFSF5 protein, TRAP protein, CD-40 protein, CD154 protein, T-BAM protein