NUDT5 is part of the nudix hydrolase family which remove toxic nucleotide derivatives from the cell. NUDT5 hydrolyzes ADP-ribose and ADP-mannose in the presence of magnesium, and in addition hydrolyzes nucleotide sugars with decreasing activity such as ADP-glucose and diadenosine diphosphate. As a nudix hydrolase, NUDT5 holds a central nudix motif and functions to eliminate toxic nucleotide metabolites from the cell while maintaining the levels of signaling nucleotides. NUDT5 is broadly expressed but is most abundant in liver as a homodimer Synonyms: hYSAH1, YSA1, YSA1H, ADP-sugar pyrophosphatase, EC=3.6.1.-, EC=3.6.1.13, Nucleoside diphosphate-linked moiety X motif 5, Nudix motif 5, HSPC115