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Description
Abl interactor (Abi) proteins are c-Abl-binding proteins that bind to both the Src homology 3 (SH3) domain and the C-terminal proline-rich regions of Abl kinase through dual SH3-PXXP interactions. Two highly related genes, abi-1 and abi-2, were cloned. In addition to the interaction with Abl kinase, Abi proteins also interact with other signaling molecules. Recently, it has been reported that Abi-1 dramatically promoted c-Abl-mediated tyrosine (Tyr296) phosphorylation of Mena [mammalian homologue of Drosophila Enabled (Ena)] by interacting with both proteins.Synonyms: Abelson interactor 1, Abi-1, Abl interactor 1, Abl-binding protein 4, AblBP4, Eps8 SH3 domain-binding protein, Nap1-binding protein, Spectrin SH3 domain-binding protein 1, Spectrin binding protein, e3B1
Immunogen
Human recombinant Abi-1 expressed in E. coli
Other Names
ABA INSENSITIVE 1|AtABI1|F20B18.190|F20B18_190|PROTEIN PHOSPHATASE 2C ABI1|abi1|wu:fc66g09|wu:fk56a10|zgc:73174|MGC84356|ABI1|abi-1|e3b1|nap1bp|ssh3bp|ssh3bp1|abi-2|abi2b|aip-1|ablbp3|argbpia|argbpib|ssh3bp2|wu:fe48a10|zgc:153534|DKFZp469P1319|ABI-1|ABLBP4|E3B1|NAP1BP|SSH3BP|SSH3BP1|NAP1|Ssh3bp1|E3b1