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Description
eNOS (Thr495) Polyclonal Antibody. ? Target Background: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
Immunogen
KLH conjugated synthetic phosphopeptide derived from human eNOS around the phosphorylation site of Thr495. Immunogen Range: 470-520/1203
Other Names
Phosphorylated, phospho-eNOS; ECNOS; Nitric oxide synthase, endothelial; Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; NOS type III; NOSIII; NOS3