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Description
CD44 is a broadly distributed transmembrane glycoprotein that plays a critical role in a variety of cellular behaviors, including adhesion, migration, invasion, and survival. CD44 mediates cell-cell and cell-matrix interactions in a large part through its affinity for hyaluronan (HA), a glycosaminoglycan constituent of extracellular matrices, but also potentially through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Variants of CD44 are expressed in tissues during development, including embryonic epithelia. known functions of CD44 are cellular adhesion (aggregation and migration), hyaluronate degradation, lymphocyte activation, lymph node homing, myelopoiesis and lymphopoiesis, angiogenesis, and release of cytokines. The functions of CD44 are principally dependant on cellular adhesion in one setting or another
Immunogen
Recombinant human CD44 (21-145aa) purified from E. coli
Other Names
CD44 antigen isoform 3 precursor, CD44 molecule (Indian blood group), MIC4, MDU2, MDU3, CD44 antigen (homing function and Indian blood group system), IN, MC56, Pgp1, CD44R, HCELL, CSPG8, hematopoietic cell E- and L-selectin ligand, chondroitin sulfate proteoglycan 8