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Description
Membrane Cofactor Protein (CD46) is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 regulates the complement cascade by inhibiting C3b and C4b deposited on self tissue. This protein is a cofactor that binds to C3b and C4b, allowing their degradation by a plasma serine protease called factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is implicated in the development and/or progression of selected cancer types.
Immunogen
Recombinant human CD46 (35-313aa) purified from E. coli
Other Names
Membrane cofactor protein isoform 14, AHuS2, MCP, MIC10, TLX, TRA2.10