A selective dopamine D3 receptor antagonist (Kis = 0.7, 93, and 375 nM for HEK293 cells expressing human D3, D2, and D4 receptors, respectively); inhibits quinpirole-induced stimulation of mitogenesis in CHO cells expressing human dopamine D3 receptors (EC50 = 3 nM); reduces progressive-ratio methamphetamine self-administration in rats allowed extended access at 32 mg/kg; reduces loss of dopaminergic neurons in the substantia nigra pars compacta and improves motor performance in the coat-hanger test in a mouse model of MPTP-induced Parkinson's disease
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
790658-27-4 PG01037 D-3 2 4 HEK-293 Chinese hamster ovary 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine