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Description
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids. Synonyms: Monoclonal ESPL1 antibody, Anti-ESPL1 antibody, Extra spindle pole bodies homolog 1 antibody, ESP1 antibody, FLJ46492 antibody, KIAA0165 antibody, SEPARIN antibody.
Immunogen
ESPL1 antibody was raised in mouse using recombinant Human Extra Spindle Pole Bodies Homolog 1 (S. Cerevisiae) (Espl1)