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Description
ERCC8/CSA Polyclonal Antibody, Alexa Fluor? 647 Conjugated. ? Target Background: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-
Immunogen
KLH conjugated synthetic peptide derived from human ERCC8/CSA. Immunogen Range: 180-230/396
Other Names
CSA; CKN1; UVSS2; DNA excision repair protein ERCC-8; Cockayne syndrome WD repeat protein CSA; ERCC8