MW: 458.44. Purity ≥98% by HPLC. CC-90003 is a potent extracellular signal-regulated kinases (ERK1/2) inhibitor. CC-90003 inhibits ERK activity, and prevents the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.