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Description
Purified anti-ADAM22. ADAM22 is a member of the ADAM (a disintegrin and metalloprotease domain) family, implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. The protein is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system.
Immunogen
This monoclonal antibody was raised against a fusion protein corresponding to amino acids 444-526 (extracellular region) of mouse ADAM22 protein.
Other Names
Disintegrin and metalloproteinase domain-containing protein 22, a disintegrin and metalloprotease domain (ADAM) 22, Metalloproteinase-disintegrin ADAM22-3, Metalloproteinase-like disintegrin-like and cysteine-rich protein 2, MDC2, MMS-5125-100