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Description
Purified anti-AKT1. AKT (Protein kinase B, PKB) is a serine/threonine kinase that plays a key role in regulating cell proliferation, survival, and metabolism. Dysregulation of AKT can lead to diseases such as cancer, diabetes, along with cardiovascular and neurological diseases. There are three isoforms of AKT- AKT1, 2, and 3 (also known as PKBα, β, and γ). AKT are activated by growth factors and other extracellular stimuli as well as by oncogenic mutations in key upstream regulatory proteins, which include Ras, PI3-kinase subunits, and PTEN. Increasing evidence suggests that AKT1, 2, and 3 plays a unique role in breast cancer initiation and progression. AKT1 is cardioprotective to the heart by supporting its physiological growth and function. A reduced level of AKT1 in the frontal cortex has been found during post-mortem brain studies of schizophrenic patients in the populations of many countries.
Immunogen
Full length recombinant protein of human AKT1 expressed in HEK293T cells.
Other Names
V-Akt Murine Thymoma Viral Oncogene Homolog 1, Protein Kinase B alpha, Rac Protein Kinase alpha, RAC-PK-alpha, PKB alpha, PRKBA, AKT, PKB, RAC, CWS6, PKB-ALPHA, RAC-ALPHA