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Description
Rabbit IgG polyclonal Picoband? antibody for Bile salt export pump(ABCB11) detection. Tested with WB, IHC-P, IHC-F, ICC, IF, FCM in Human;Mouse;Rat. No cross reactivity with other proteins. Bile Salt Export Pump (BSEP) is a protein which in humans is encoded by the ABCB 11 gene. It is a member of the superfamily of ATP-binding cassette (ABC) transporters, also known as ABCB11. It is mapped to chromosome 2q24. The BSEP protein is mainly expressed in the liver. ABCB11 is a gene associated with progressive familial intrahepatic cholestasis type 2 (PFIC2) which caused by mutations in the ABCB11 gene will increases the risk of hepatocellular carcinoma in early life.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human ABCB11 (1175-1199aa KYGDNTKEIPMERVIAAAKQAQLHD), different from the related mouse and rat sequences by three amino acids.
Other Names
Bile salt export pump;ATP-binding cassette sub-family B member 11;ABCB11;BSEP;