Immunohistochemistry (Paraffin): 1:1000-1:5000, Immunoprecipitation: 1:50-1:200, Western Blot: 1:1000-1:2000
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Description
DEDD2 Polyclonal Antibody. Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that
Immunogen
n/a
Other Names
PSEC0004, FLAME-3; DED-containing protein FLAME-3; DNA-binding death effector domain-containing protein 2; FADD-like anti-apoptotic molecule 3; death effector domain-containing DNA binding protein 2