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Description
Antigen: mixture of synthetic peptides corresponding to rat caspase-9 amino acids 345-359 and 366-383 ? Host: rabbit ? Cross Reactivity: (+) human, mouse, and rat caspase-9 ? Application(s): WB ? CTD is a novel isoform of rat caspase-9 in which the C-terminus of full-length caspase-9 is replaced with an alternative peptide sequence. It is found primarily in the cytoplasm and was not detected in the nucleus. CTD proenzyme is not processed in the cells and lacks apoptotic activity. The CTD-transfected cells are resistant to caspase induction by cytochrome c, suggesting the CTD acts as a dominant-negative variant.
Immunogen
mixture of synthetic peptides corresponding to rat caspase-9 amino acids 345-359 and 366-383