A small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172
Size
50 mg
Concentration
n/a
Applications
n/a
Other Names
obesity syndromes kinases diabetes atherosclerosis AMP-activated proteins kinases AMPK lipids metabolisms glucose metabolic stress activators activates active glucose uptakes diseases A769662 A-769662 A 769662 A769,662 A 769,662 A-792,662 thienopyridone inhibits inhibiting inhibitions inhibitors CYP450 fatty acids oxidations adipocytes differentiations uptake up-take alpha .alpha. a beta .beta. b gamma .gamma. g heterotrimers sensors regulates regulating cells cellular energy homeostasis small molecules thienopyridones cell-free assays intact allosterically Thr172 stimulates CYP450-mediated cytochromes P450 dephosphorylations skeletal muscles endothelium endothelial