Human IFN Gamma / Interferon Gamma Protein (Recombinant)
Description
Purity >95% by SDS-PAGE, MW: 17 kDa. Human Interferon gamma (hIFN-gamma) is amacrophage-activating factor and the lone member of Interferon type II.The active form of IFN-gamma is an antiparallel dimer that interacts with the receptor IFN-gammaR1 and sets off IFN-gamma/JAK/STAT pathway. IFN-gamma signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. While IFN-gamma-induced inflammatory cascade summons a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers. Recombinant human Interferon gamma (rhIFN-gamma) produced in E. coli is a non-glycosylated polypeptide chain of 144 amino acids. A fully biologically active molecule, rhIFN-gamma has a molecular mass of 17 kDa analyzed by reducing SDS-PAGE and is obtained by refolding and chromatographic techniques.