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Description
CD14 recognizes a human monocyte/macrophage antigen of 55 kilodaltons (kd). It reacts with blood monocytes and has a weak reactivity on blood granulocytes, and interfollicular macrophages. Different cytokines have an effect on CD14 expression: CD14 expression was studied in dendritic cells generation in vitro. After 5 days in GMCSF + IL4, CD14 disappears while CD1a expression appears.TNF-alpha skews monocyte differentiation form macrophages to dendritic cells. L'anticorps MOP9-25 is utilized for monocyte depletion before dendritic cells sorting. Dimitriu-Bona A., et al., J Immunol,1983,130,145- ;Banchereau J. et al., Annu Rev Immunol. 2000, 18, 767-;Chomarat P. et al., J Immunol, 2003,171, 2262-.