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Description
An antibody has been generated that specifically recognizes human follicular dendritic cells (FDCs) on the long CR2 / CD21L isoform (CD21L). Follicular dendritic cells represent a cell-type ontogenetically distinct from all other Dendritic Cells (DCs). They are found within B lymphocyte follicles of secondary lymphoid tissue. At the opposite, B lymphocytes selectively express the short CR2 / CD21 lacking exon 10a (CD21S). mAb 7D6 does not recognize CD21 expressed on other cells. (Liu Y.J. et al, 1997; J. Exp. Med.185: 165-170)