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Description
117G12 monoclonal antibody was obtained following mouse immunization with in vitro-derived human dendritic cells. The target antigen was found to be CD54/ICAM-1, a cell surface glycoprotein which is typically expressed on endothelial cells and immune cells. CD54/ICAM-1, member of the Ig superfamily, binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also a receptor for rhinovirus. CD54/ICAM-1 is a type of intracellular adhesion molecule, playing a role in transmigration of endothelial cells into tissues through binding to LFA-1. mAb 117G2 positively stains sheep tissue sections (Schwartz-Cornil I, pers.communication ; Carlson M.et al, 1988, Nucleic Acids Res. 16 (9): 4188; Yang L. et al, 2005, Blood 106 (2): 584