cell culture inhibition in MELR H3 thymidine uptake proliferative assay, IF
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Description
CD40 ligand also known as TRAP, gp39, TNFSF5, is a 261 amino acid type II transmembrane glycoprotein belonging to the TNF superfamily. CD40 ligand is expressed predominantly on activated CD4+ T cells and is also found on other cell types, including NK cells, mast cells, basophils and eosinophils. Genetic alterations in the CD40L results in the absence of a functional molecule on activated T cells and are responsible for the occurrence of X-linked hyper-IgM syndrome. LL48 clone is a CD40L neutralizing antibody and plays an important role in costimulatory interactions between T and B lymphocytes, and antigen-presenting cells and lymphocytes regulating the immune system at multiple levels. (Tong AW et al, 2001; Clin. Canc. Res., 7:691-703; Hill A. et al, 1993; Nature, 361:494-503; Peguet-Navarro J. et al, 1995; J. Immunol., 155:4241-4247)