Fpg is a DNA glycosylase that releases damaged bases preferentially from duplex DNA. It has an associated class I AP (apurinic/apyrimidinic) lyase activity.Fpg Cleaves the DNA backbone to generate a single-strand break at the site of the removed base, The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving 3' and 5' phosphoryl groups.Alternative Names: Formamidopyrimidine-DNA Glycosylase, Fapy-DNA Glycosylase, DNA-(Apurinic or Apyrimidinic Site) Lyase MutM, AP Lyase MutM, mutM, fpg