human, rat, mouse, zebrafish, other species not tested yet.
Isotype
IgG1
Format
purified
Size
100 μg
Concentration
n/a
Applications
IHC, Paraffin Sections (FFPE), Frozen Sections, Western Blot, Immunoprecipitation
Reviews / Ratings
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Description
Two isoforms (D28k and D29k) of the vitamin D-dependent Ca-binding proteins called calbindins have been described so far. These proteins are expressed in cells that have to handle a high calcium influx such as brain, bone, teeth, inner ear and others. Calbindins are believed to regulate cellular activity by suppressing or buffering intracellur calcium.
Immunogen
Recombinant protein of human calbindin D28k (aa 3 - 251).
Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer. Bortolussi G, Zentilin L, Baj G, Giraudi P, Bellarosa C, Giacca M, Tiribelli C & Muro AF. FASEB Journal 26: 1052-63, 2012. / Probing the Functional Equivalence of Otoferlin and Synaptotagmin 1 in Exocytosis. Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, Nouvian R, Koch M, Buckers J, Kastrup L, Roux I, Petit C, Hell SW, Brose N, Rhee JS, Kugler S, Brigande JV & Moser T. Journal of Neuroscience 31: 4886-95, 2011. / Slow age-dependent decline of doublecortin expression and BrdU labeling in the forebrain from lesser hedgehog tenrecs. Alpar A, Kunzle H, Gartner U, Popkova Y, Bauer U, Grosche J, Reichenbach A & Hartig W.. Brain Research 1330: 9-19, 2010.