If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Antibody clone SZ31 is the first antibody which reacts specifically with murine CD31 in formalin-fixed paraffin-embedded tissue sections. Does not crossreact with rat or human. Studies have shown CD31 to be a superior marker in human angiogenesis, which reportedly predicts tumor recurrence. Pathophysiological studies of CD31 in murine model systems had limitations because standard formalin-fixed sections were excluded. The clone SZ31 eliminates these restrictions by allowing high quality immunohistochemical analysis of standard formalin-fixed paraffin sections in mice.
Immunogen
Murine amino acid fragment (amino acids 610-681 of mouse CD31)
Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury. Holscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A. J.Biol.Chem. 286: 11185-11194, 2011. Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues. Kroger C, Vijayaraj P, Reuter U, Windoffer R, Simmons D, Heukamp L, Leube R, Magin TM. Am.J.Pathol. 178(4): 1587-1590, 2011. NAHA, a Novel Hydroxamic Acid-Derivative, Inhibits Growth and Angiogenesis of Breast Cancer In Vitro and In Vivo. Jiang J, Thyagarajan-Sahu A, Krch?ak V, Jedinak A, Sandusky GE, et al. PLoS ONE 7(3): e34283, 2012. Reduces Spontaneous Metastatic Spread of Prostate Cancer in the TRAMP. Copeland BT, Bowman MJ, Ashman LK. Genetic Ablation of the Tetraspanin CD151 Model. Mol Cancer Res. 11(1):95-105, 2013. Therapeutic ef-fect of lenalidomide in a novel xenograft mouse model of human blastic NK cell lymphoma/blastic plasmacytoid dendritic cell neoplasm. Agliano A, Martin-Padura I, Marighetti P, Gregato G, Calleri A, Prior C, Redrado M, Calvo A, Bertolini F. Clin Cancer Res. 1;17(19):6163-73, 2011. Absence of IL-12R?2 in CD33(+)CD38(+) pediatric acute myeloid leukemia cells favours progression in NOD/SCID/IL2R?C-deficient mice. Ferretti E, Montagna D, Di Carlo E, Cocco C, Ribatti D, Ognio E, Sorrentino C, Lisini D, Bertaina A, Locatelli F, Pistoia V, Airoldi I. Leukemia 26(2):225-35, 2012.