IHC, Paraffin Sections (FFPE), Frozen Sections, Immunocytochemistry, Western Blot
Reviews / Ratings
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Description
Clathrin consists of heavy chains and light chains that co-assemble to triskelions. The light chains (A and B) are differentially spliced, with neurons expressing a special variant that is not detectable elsewhere. The neuron-specific light chains are enriched in synaptic nerve terminals where they participate in synaptic vesicle endocytosis.
Immunogen
Synthetic peptide IADKAFYQQPDADTIGYV (aa 156-173) corresponding to the spliced insert of the neuronal light chain variants.
The expression pattern and assembly profile of synaptic membrane proteins in ribbon synapses of the developing mouse retina. von Kriegstein K & Schmitz F. Cell Tissue Research 311: 159-73, 2003. / Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses. von Kriegstein K, Schmitz F, Link E & Sudhof T. European Journal of Neuroscience 11: 1335-48, 1999.